Week 6 NFL Picks, Predictions, Odds, Best Bets from the Vegas Expert: This three-team football game pays 6-1

Last season the underdogs with at least seven points had a head-to-head record of 15-50, but this year they are 7-2. That’s something to keep in mind when making your Week 6 NFL bets, as these touchdown-plus-dogs’ 77.8% win rate this year is their best five-week record since the 1970 merger. The Week 6 NFL schedule features a heavy underdog as Philadelphia is the 8.5-point favorite over Cleveland in a game with a low over-under of 42. Philadelphia could be lethargic after a bye against a Browns team desperate for a win You may want to get NFL betting advice on both NFL straight-up picks and NFL against-the-spread picks. Before making any NFL picks or NFL competitions for Week 6, be sure to read what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines an extensive network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Hartstein placed 52nd (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest with an ATS of 53-34-3. His weekly selection of Vegas contests forms the basis of his best NFL bets column, which is 84-57-3 (59.6%, +20.90 units) since its inception in 2022.

For Week 6, Hartstein has secured three confident best bets. If you use his tips successfully, you can expect a payout of almost 6:1. You can see Hartstein’s Week 6 NFL picks only at SportsLine.

Top NFL picks of Week 6

We can tell you that Hartstein loves seeing the Titans (-2.5, 42.5) cover at home against the Colts in an AFC South game. This is a perfect date for a Titans team that won a bye the week before against a weakened Colts team that just gave the Jaguars their first win. Both Trevor Lawrence (371 passing yards) and Tank Bigsby (101 rushing yards) posted career highs against Indianapolis, which ranked last in the NFL in yards allowed, second-worst in rush yards given up and second-worst in pass yards allowed the fourth worst place.

Meanwhile, the Titans were able to improve their running game before their bye, matching their season high of 142 yards. Additionally, kicker Nick Folk is a perfect 15-for-15 on all attempts, while the Titans have committed the second-fewest penalties this season. Add to that the fact that the Titans have played their last six games following a bye, and Hartstein still likes Tennessee, even if the line has moved from +1.5 to -2.5. Check out what other NFL combo picks you can make here.

How to make NFL pays for Week 6

Hartstein also took part in two other NFL matches, including supporting a shocking underdog whose opponent was missing a “decision maker” due to injury. At SportsLine you can only see Hartstein’s top NFL bets and bets from Week 6.

What are Hartstein’s top NFL picks for Week 6 and which NFL matchups should you target to score an epic 6-1 payout? Visit SportsLine now to see the best NFL bets of Week 6 from the Vegas expert, who is up 20.90 units on NFL ATS picks, and find out.