Week 6 NFL odds, expert picks, best bets, spreads, teasers, survival tips, TV, live streaming and more

The 2024 NFL season has brought its fair share of surprises, from the Minnesota Vikings getting off to a perfect 5-0 start against the Kansas City Chiefs to the Cincinnati Bengals losing despite an explosive return from Joe Burrow Stumbling at the end of the AFC North. There often doesn’t seem to be a “safe bet” on the weekly NFL calendar, but we’re still here to help you predict what’s ahead.

We’ve collected the best tips and gambling content from CBSSports.com and SportsLine and combined them in one place so you can get tips against the spread from our CBS Sports experts, as well as additional feature content for every game, including plays from top experts from SportsLine and the SportsLine Projection Model, our staff’s best bets, survivor picks and more. Ready? Let’s get in.

All NFL odds via SportsLine Consensus Odds.

Jaguars at Bears

Time: Sunday, 9:30 a.m. ET (NFL Network), stream on fubo (try for free)
Open: Jaguars -1, O/U 46.5

SportsLine’s projection model simulates every NFL game 10,000 times and is up to $7,900 for $100 players on top-rated picks since its inception. In Week 6, we can tell you that the model predicts a 25-21 win for the Bears, who secure outright victory in almost 60% of simulations. The Jaguars celebrate their first win of the season, but have major problems defensively. Check out the full SportsLine projection for this matchup and other Week 6 tips here.

Cardinals at Packers

Time: Sunday, 1:00 p.m. ET (Fox), streaming on fubo (try for free)
Open: Packer -4.5, O/U 47.5

“Arizona has been a fun team this year and their scoring pace so far has been impressive. Kyler Murray didn’t do much after a 50-yard rush against San Francisco, but I would have expected him to do a little better than that. He was productive in this matchup, especially with Trey McBride serving as a fully functional target eater. The Packers have looked strong on offense all season and should be capable of some explosive plays in this matchup with Jordan Love fully healthy and Dontayvion Wicks can’t play any worse!

CBS Sports senior writer Will Brinson wants the over to be reached in this matchup. Check out the rest of his best bets and predictions for Week 6 right here.

Colts at Titans

Time: Sunday, 1 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Colts -2, O/U 45

SportsLine expert Larry Hartstein combines an extensive network of Vegas sources with an analytical approach he honed while working for Pro Football Focus to predict every week of NFL action, and he’s now 84-57-3 (59th). .6%) with weekly Vegas competition tips achieved in 2022. We can tell you that Hartstein loves to see the Titans cover against the Colts: “In the last 42 games of their loss to Jacksonville, the Colts have given up 419 yards, almost 10 Yards per play. This is the ultimate right place for.” “A Titans offense that leans on Will Levis,” he told SportsLine. Check out his full breakdown and prediction here.

Texans at Patriots

Time: Sunday, 1:00 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Texans -4.5, O/U 42.5

“Drake Maye will be the starting quarterback for the lowly Patriots, but did you know rookie quarterbacks have been covering? and won seven starts in a row? Additionally, 7+ point underdogs have an incredible 7-2 consecutive record this season, easily the best 7+ point underdog record in a five-week period since 1970. For comparison, underdogs with more than 7 points went 15-50 in 2023. The Patriots don’t have an offensive line or skill weapons to secure Pro Bowl votes, but the Texans just lost Nico Collins for at least four games while Joe Mixon and three offensive linemen missed practice on Wednesday. New England stays close.”

CBS Sports writer Jordan Dajani believes Houston will come away with the “W,” but not in an overwhelming way. Check out his full analysis and other best bets from Week 6. right here.

Buccaneers at Saints

Time: Sunday, 1:00 p.m. ET (Fox), streaming on fubo (try for free)
Open: Saints -1, O/U 42

“This is a bad situation for the Saints. Aside from Derek Carr being ailing, New Orleans is preparing for an important divisional game in a short week against a Buccaneers club that has had a mini-break week after its game last Thursday.” Baker Mayfield has in played at an extremely high level this season and is 9-2 ATS as the Bucs starter. The residual advantage and the pain of losing an overtime game to Atlanta in Week 5 should give Tampa Bay the momentum it needs to go on the road and get a win.

CBS Sports writer Tyler Sullivan focuses on Tampa Bay in this article. Check out his full Week 6 breakdown, with the best bets and tips for all the key matchups. right here.

Browns at Eagles

Time: Sunday, 1:00 p.m. ET (Fox), streaming on fubo (try for free)
Open: Eagles -3, O/U 46.5

SportsLine’s projection model enters Week 6 with a 10-2 streak among this year’s top-rated NFL picks. When predicting the safest survivor pool picks for this weekend, we can tell you that the model is shying away from the Eagles, even though Philadelphia is the week’s biggest favorite. Philly scored a season-high 33 points in its final game, while Cleveland performed surprisingly well in the red zone. While the Eagles are projected to win in well over 60% of simulations, the model is saving Philadelphia for another week. For a full breakdown of the best survival options, head to SportsLine.

Commanders at Ravens

Time: Sunday, 1 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Ravens -6.5, O/U 49.5

“Look, I don’t want to take anything away from what the Commanders have done – Jayden Daniels was great and Washington finally has a franchise quarterback – but I have to say, I’m not completely sold on them yet.” Their four wins came against four teams that are a combined 6-14. They haven’t beaten a team that currently has a winning record, and their defense is completely inconsistent in part because Lamar Jackson never loses to NFC teams. He is 21-1 against the NFC over his career, a record that includes nine straight wins.

CBS Sports writer John Breech respects Washington’s rise, but he’s rooting for Baltimore to stop the Commanders’ hype train. Check out all of his Week 6 predictions right here.

Chargers at Broncos

Time: Sunday, 4:05 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Chargers -2.5, O/U 42.5

Developed by SportsLine’s data science team using state-of-the-art artificial intelligence and machine learning techniques, AI Predictions and AI Ratings predict every single game of the season. For Week 6, the AI ​​PickBot predicts the Broncos will cover as 3-point home underdogs against the Chargers. Justin Herbert is still battling a right ankle sprain he suffered in a loss to the Chiefs and could have limited mobility this week even after a bye. That’s not ideal against a Denver defense that ranks second in points allowed and third in yards allowed. Check out the full overview of AI-powered tips here.

Steelers at Raiders

Time: Sunday, 4:05 p.m. ET (CBS), streaming on Paramount+ (click here)
Open: Steelers -1, O/U 43.5

“Aidan O’Connell replaces Gardner Minshew, who was substituted last week. He will face a good Pittsburgh defense. The Steelers will counter with Justin Fields, who needs a good game to silence the critics and the Russell Wilson talk.” I think Fields will outplay O’Connell to win for the Raiders.

CBS Sports senior columnist Pete Prisco doesn’t buy into the idea that Antonio Pierce’s recent quarterback change will spark a major turnaround for Las Vegas. Find all of Prisco’s Week 6 predictions here right here.

Lions with cowboys

Time: Sunday, 4:25 p.m. ET (Fox), stream on fubo (try for free)
Open: Lions -3, O/U 50.5

“Dallas needed a last-second touchdown to defeat a wildly inefficient Steelers offense on Sunday night. In Week 6, the Cowboys will have a much more fine-tuned opponent in the Lions, who will enter AT&T Stadium as the away favorite. Under Dan Campbell The Lions are 0-4 ATS as away favorites. Also worth noting is the residual advantage Detroit will have after the road game. The Lions are 10-2 ATS in their last 12 games following the bye week.

According to CBS Sports writer Tyler Sullivan, all signs point to a decisive Detroit win. Find all of his picks and best bets for Week 6 here right here.

Falcons at Panthers

Time: Sunday, 4:25 p.m. ET (Fox), stream on fubo (try for free)
Open: Falcons -3, O/U 42.5

SportsLine’s Projection Model has ranked in the top 10 in straight NFL picks on NFLPickWatch in four of the last six years, beating more than 94% of CBS Sports’ football pick’em players four times during that period. For Week 6, we can tell you that the model likes the Falcons to cover the spread against the Panthers well over 50% of the time, making Atlanta one of the stronger games this weekend. Check out SportsLine’s full breakdown of recommended picks here.

Bengals at Giants

Time: Sunday, 8:20 p.m. ET (NBC), stream on Fubo (try for free)
Open: Bengals -5.5, O/U 44

RJ White, senior fantasy and gambling editor for CBS Sports, has twice won big money in the world’s most prestigious handicapping tournament, the Westgate Las Vegas SuperContest. He also has his finger on the pulse of the Giants, going 52-27 (+2176) in his last 79 picks with New York. Does he like Daniel Jones and Co. causing problems for the defensively struggling Bengals in prime time? His full breakdown and prediction for this contest can be found here at SportsLine.

Bills at Jets

Time: Monday, 8:15 p.m. ET (ESPN), stream on fubo (try for free)
Open: Nozzles -1.5, O/U 46.5

SportsLine expert Mike Tierney is 154-124-9 making NFL picks over the past two seasons, returning $1,586 to $100 players (each bet 1 unit). He also has a firm grip on the Bills, posting a 41-27-4 (+1162) record in his last 72 picks with Buffalo. Does he think the Jets’ sudden coaching change, the loss of Robert Saleh and the replacement of Nathaniel Hackett at offensive line, will help Aaron Rodgers and Co. to a prime-time victory over their AFC East rival? His full analysis and forecast can be found here.